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WE2 - Tutorial & Novel Tissue Imaging and Detection Techniques Session Presider: Martin Villiger
10:30-12:00 Salon VII
WE2.1 -
Multifunctional Imaging of Human Tissue by Jones Matrix Optical Coherence Tomography Tutorial
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America/Denver Multifunctional Imaging of Human Tissue by Jones Matrix Optical Coherence Tomography Jones matrix optical coherence tomography (JM-OCT) is the most geenral form of OCT, which measures full Jones matrix distribution of a sample. Clinically usesul imaforamtion including scattering, flow, birefringence, and melanin distributions were deduced from the Jones matrix. We present ophthalmic and dermatologic applications. Hilton Santa Fe Historic Plaza Salon VII

    Y. Yasuno , University of Tsukuba, Tsukuba, Ibaraki, Japan

    Jones matrix optical coherence tomography (JM-OCT) is the most geenral form of OCT, which measures full Jones matrix distribution of a sample. Clinically usesul imaforamtion including scattering, flow, birefringence, and melanin distributions were deduced from the Jones matrix. We present ophthalmic and dermatologic applications.
WE2.2 -
Dual Detection of Zika Virus Nucleic Acid and Protein Using a Multi-Mode Interference Waveguide Platform
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America/Denver Dual Detection of Zika Virus Nucleic Acid and Protein Using a Multi-Mode Interference Waveguide Platform We report a novel technique for simultaneous detection of nucleic acid and protein biomarkers using multimode interference (MMI) waveguides on an optofluidic chip. Multiplex detection of Zika virus nucleic acids and proteins using two-color multi-spot excitation is demonstrated with excellent specificity. Hilton Santa Fe Historic Plaza Salon VII

    A. Stambaugh , UC Santa Cruz, Santa Cruz, CA, United States, J. Parks , UC Santa Cruz, Santa Cruz, CA, United States M. Stott , BYU , Provo, UT, United States G. Meena , UC Santa Cruz, Santa Cruz, CA, United States A. Hawkins , BYU, Provo, UT, United States H. Schmidt , UC Santa Cruz, Santa Cruz, CA, United States

    We report a novel technique for simultaneous detection of nucleic acid and protein biomarkers using multimode interference (MMI) waveguides on an optofluidic chip. Multiplex detection of Zika virus nucleic acids and proteins using two-color multi-spot excitation is demonstrated with excellent specificity.
WE2.3 -
High-throughput single-cell second harmonic generation imaging in ultrafast microfluidic flow
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America/Denver High-throughput single-cell second harmonic generation imaging in ultrafast microfluidic flow We demonstrate high-throughput second harmonic generation imaging of single cells in flow at a throughput of 10,000 cells/sec – enabled by an all-optical laser scanning imaging technique, coined free-space angular-chirp-enhanced delay (FACED), combined with a high-speed time-gated photon counting detection scheme. Hilton Santa Fe Historic Plaza Salon VII

    J. Wu , The University of Hong Kong, Hong Kong, Hong Kong, Q. Lai , The University of Hong Kong, Hong Kong, Hong Kong W. Yan , The University of Hong Kong, Hong Kong, Hong Kong K. Wong , The University of Hong Kong, Hong Kong, Hong Kong K. Tsia , The University of Hong Kong, Hong Kong, Hong Kong

    We demonstrate high-throughput second harmonic generation imaging of single cells in flow at a throughput of 10,000 cells/sec – enabled by an all-optical laser scanning imaging technique, coined free-space angular-chirp-enhanced delay (FACED), combined with a high-speed time-gated photon counting detection scheme.
WE2.4 -
CMOS fabricated large array of free standing substrate-less photonic crystal cavities for biosensing applications
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America/Denver CMOS fabricated large array of free standing substrate-less photonic crystal cavities for biosensing applications In this work, we present a methodology to post-process a large array of a few hundred nanometer thin photonic membranes that were fabricated using complementary metal-oxide semiconductor (CMOS) technological platform. The post processing results in local removal of the silicon substrate and of the buried oxide (BOX), which provides a free access from both side of the photonic structures. The membranes are patterned with photonic crystal (PhC) cavities by deep ultraviolet (UV) lithography. We show that the proposed process is compatible with the integration of micrometer-sized SU8 based polymer waveguides. These polymer waveguides together with high index contrast adiabatic nanometer-sized silicon inverted tapers act as spot size converters. Hilton Santa Fe Historic Plaza Salon VII

    K. Saurav , imec-Ghent university, Gent, Belgium

    In this work, we present a methodology to post-process a large array of a few hundred nanometer thin photonic membranes that were fabricated using complementary metal-oxide semiconductor (CMOS) technological platform. The post processing results in local removal of the silicon substrate and of the buried oxide (BOX), which provides a free access from both side of the photonic structures. The membranes are patterned with photonic crystal (PhC) cavities by deep ultraviolet (UV) lithography. We show that the proposed process is compatible with the integration of micrometer-sized SU8 based polymer waveguides. These polymer waveguides together with high index contrast adiabatic nanometer-sized silicon inverted tapers act as spot size converters.